Thiol redox control via thioredoxin and glutaredoxin systems.
نویسندگان
چکیده
The Trx (thioredoxin) and Grx (glutaredoxin) systems control cellular redox potential, keeping a reducing thiol-rich intracellular state, which on generation of reactive oxygen species signals through thiol redox control mechanisms. Here, we give a brief overview of the human Trx and Grx systems. The main part focuses on our current knowledge about mitochondrial Grx2, which facilitates mitochondrial redox homoeostasis during oxidative stress-induced apoptosis.
منابع مشابه
Invited Review CALL FOR PAPERS Oxygen Sensing: Life and Death of a Cell Thiol-based mechanisms of the thioredoxin and glutaredoxin systems: implications for diseases in the cardiovascular system
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ورودعنوان ژورنال:
- Biochemical Society transactions
دوره 33 Pt 6 شماره
صفحات -
تاریخ انتشار 2005